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Intravitreal allogeneic mesenchymal stem cells: a non-randomized phase II clinical trial for acute non-arteritic optic neuropathy
CONCLUSIONS: Besides the development of an epiretinal membrane in one patient, the intravitreal application of allogeneic BM-MSCs appeared to be intraocularly well tolerated. Consequently, not only NA-AION but also BM-MSCs deserve more clinical investigational resources and a larger randomized multicenter trial that would provide stronger evidence both about safety and the potential therapeutic efficacy of intravitreally injected allogeneic BM-MSCs in acute NA-AION.TRIAL REGISTRATION: Safety Assessment of Intravitreal Mesenchymal Stem Cells for Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NEUROSTEM). NCT03173638...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Jose C Pastor Salvador Pastor-Idoate Marina L ópez-Paniagua Marta Para Francisco Blazquez Esther Murgui Ver ónica García Rosa M Coco-Mart ín Source Type: research

Retinal Imaging And Machine Learning Honored In The 2023 Lasker Awards
The Lasker Foundation ’s annual awards for medical research honor the inventors of optical coherence tomography and more.
Source: Forbes.com Healthcare News - September 21, 2023 Category: Pharmaceuticals Authors: Alex Knapp, Forbes Staff Tags: Science /science Innovation /innovation Healthcare /healthcare AI /ai Editors' Pick editors-pick technology alexknappblog premium Source Type: news

Hyperbaric oxygen therapy suppresses hypoxia and reoxygenation injury to retinal pigment epithelial cells through activating peroxisome proliferator activator receptor-alpha signalling
J Cell Mol Med. 2023 Sep 20. doi: 10.1111/jcmm.17963. Online ahead of print.ABSTRACTRetinal ischemia followed by reperfusion (IR) is a common cause of many ocular disorders, such as age-related macular degeneration (AMD), which leads to blindness in the elderly population, and proper therapies remain unavailable. Retinal pigment epithelial (RPE) cell death is a hallmark of AMD. Hyperbaric oxygen (HBO) therapy can improve IR tissue survival by inducing ischemic preconditioning responses. We conducted an in vitro study to examine the effects of HBO preconditioning on oxygen-glucose deprivation (OGD)-induced IR-injured RPE ce...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Tzong-Bor Sun Kuo-Feng Huang Ko-Chi Niu Cheng-Hsien Lin Wen-Pin Liu Chao-Hung Yeh Shu-Chun Kuo Ching-Ping Chang Source Type: research

Retinopathy is associated with impaired cognition in patients undergoing peritoneal dialysis
Conclusions: Retinopathy, a condition common in patients undergoing PD, was associated with global cognitive impairment. These findings highlight retinopathy, can serve as a valuable primary screening tool for assessing the risk of cognitive decline.PMID:37732397 | DOI:10.1080/0886022X.2023.2258989
Source: Renal Failure - September 21, 2023 Category: Urology & Nephrology Authors: Jinlan Liao Qijie Wei Yingying He Yumei Liao Zibo Xiong Qing Wang Dayong Ding Xiaoyan Huang Zuying Xiong Yonggui Wu Source Type: research

Hyperbaric oxygen therapy suppresses hypoxia and reoxygenation injury to retinal pigment epithelial cells through activating peroxisome proliferator activator receptor-alpha signalling
J Cell Mol Med. 2023 Sep 20. doi: 10.1111/jcmm.17963. Online ahead of print.ABSTRACTRetinal ischemia followed by reperfusion (IR) is a common cause of many ocular disorders, such as age-related macular degeneration (AMD), which leads to blindness in the elderly population, and proper therapies remain unavailable. Retinal pigment epithelial (RPE) cell death is a hallmark of AMD. Hyperbaric oxygen (HBO) therapy can improve IR tissue survival by inducing ischemic preconditioning responses. We conducted an in vitro study to examine the effects of HBO preconditioning on oxygen-glucose deprivation (OGD)-induced IR-injured RPE ce...
Source: J Cell Mol Med - September 21, 2023 Category: Molecular Biology Authors: Tzong-Bor Sun Kuo-Feng Huang Ko-Chi Niu Cheng-Hsien Lin Wen-Pin Liu Chao-Hung Yeh Shu-Chun Kuo Ching-Ping Chang Source Type: research

Genetic and clinical landscape of ARR3-associated MYP26: the most common cause of Mendelian early-onset high myopia with a unique inheritance
Conclusion This study reveals ARR3 as the most frequently implicated gene for Mendelian eoHM. Truncations and highly scored missense variants in ARR3 are pathogenic. Myopia due to ARR3 mutations is transmitted in X-linked female-limited inheritance, manifests with mild cone impairment and slowly progresses to pathologic myopia. Identification of the most common cause for Mendelian eoHM provides a valuable starting point into the molecular mechanism of myopia.
Source: British Journal of Ophthalmology - September 21, 2023 Category: Opthalmology Authors: Wang, Y., Xiao, X., Li, X., Yi, Z., Jiang, Y., Zhang, F., Zhou, L., Li, S., Jia, X., Sun, W., Wang, P., Zhang, Q. Tags: Open access Original articles - Clinical science Source Type: research

Hand grip strength and ocular associations: the Ural Eye and Medical Study
Conclusions and relevance In addition to parameters such as lower physical activity, higher depression score and worse general health status, a reduced HGS is associated with visual impairment, shorter axial length, lower intraocular pressure, thinner peripapillary retinal nerve fibre layer and higher prevalence of diabetic retinopathy. HGS dynamometry or a handshake may provide the ophthalmologist additional clinical information about the general health and ocular parameters of the patient.
Source: British Journal of Ophthalmology - September 21, 2023 Category: Opthalmology Authors: Bikbov, M. M., Zainullin, R. M., Gilmanshin, T. R., Iakupova, E. M., Kazakbaeva, G. M., Panda-Jonas, S., Tuliakova, A. M., Fakhretdinova, A. A., Gilemzianova, L. I., Jonas, J. B. Tags: Original articles - Clinical science Source Type: research

Mutations in VWA8 cause autosomal-dominant retinitis pigmentosa via aberrant mitophagy activation
Conclusions VWA8 plays a significant role in retinal development and visual function. This finding may provide new insights into RP pathogenesis and potential genes for molecular diagnosis and targeted therapy.
Source: Journal of Medical Genetics - September 21, 2023 Category: Genetics & Stem Cells Authors: Kong, L., Chu, G., Ma, W., Liang, J., Liu, D., Liu, Q., Wei, X., Jia, S., Gu, H., He, Y., Luo, W., Cao, S., Zhou, X., He, R., Yuan, Z. Tags: Genotype-phenotype correlations Source Type: research

Retinal medical treatments: 2023, pivotal year
J Fr Ophtalmol. 2023 Sep 18:S0181-5512(23)00399-6. doi: 10.1016/j.jfo.2023.09.001. Online ahead of print.NO ABSTRACTPMID:37730497 | DOI:10.1016/j.jfo.2023.09.001
Source: Journal Francais d Ophtalmologie - September 20, 2023 Category: Opthalmology Authors: J-F Korobelnik Source Type: research

Central retinal vein and artery occlusion associated with sildenafil: a case report and review of the literature
ConclusionSildenafil may be associated with severe retinal vascular accidents in otherwise healthy young individuals.
Source: Journal of Medical Case Reports - September 20, 2023 Category: General Medicine Source Type: research

Preoperative estimation of retinal hole location using ultra-wide-field imaging
CONCLUSION: It is feasible to locate retinal holes using UWF fundus photography before SB, which is helpful for quick localization, thereby reducing the learning curve of SB surgery.PMID:37725940 | DOI:10.1080/07853890.2023.2258790
Source: Annals of Medicine - September 19, 2023 Category: Internal Medicine Authors: Donghui Li Nalei Zhou Rui Gao Jialiang Duan Qingli Shang Source Type: research

Cilioretinal artery occlusion secondary to central retinal vein occlusion
Can J Ophthalmol. 2023 Sep 16:S0008-4182(23)00271-5. doi: 10.1016/j.jcjo.2023.08.010. Online ahead of print.NO ABSTRACTPMID:37726095 | DOI:10.1016/j.jcjo.2023.08.010
Source: Canadian Journal of Ophthalmology - September 19, 2023 Category: Opthalmology Authors: Heather M McDonald Armin Handzic Edward Margolin Source Type: research

A novel primary porcine retinal pigment epithelium cell model with preserved properties
CONCLUSIONS: This work describes, for the first time, a pRPE cell model that exhibits preserved RPE properties for several passages on cell culture plastic plates. Though RPE characteristics were maintained for at least 6 passages, the reduced CRALBP and RPE-65 with passaging emphasize that lower passage cells are advantageous to utilise, and that morphology, barrier function and ZO-1 localisation cannot be solely employed as a quality measure of RPE identity. Pigs are phylogenetically similar to humans, including similar physiology, anatomy and immune system. Therefore, porcine RPE cells constitute a relevant model system...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Dinna Zhou Anne Petersen Julia Adel öf Malin Hernebring Madeleine Zetterberg Source Type: research

Optical coherence tomography angiography in birdshot chorioretinopathy
CONCLUSION: Our study demonstrates the potential contribution of OCTA as a new non-invasive imaging technology that monitors disease activity in BSCR patients.PMID:37723901 | DOI:10.1177/11206721231203265
Source: European Journal of Ophthalmology - September 19, 2023 Category: Opthalmology Authors: Francesco Pichi Andrea Lembo Paolo Nucci Piergiorgio Neri Source Type: research